Human Research
Assessment of motor thresholds and neuronal plasticity using nrTMS.
Therapeutic navigational rhythmic transcranial magnetic stimulation (nrTMS) in a patient with depression.
Study of neurophysiological endophenotypes of emotion perception in humans using eye-tracking technology.
Study of neurophysiological endophenotypes of emotion perception using evoked EEG (middle- and long‑latency ERPs) in health and in affective and psychosomatic disorders.
Personalized neurotechnologies of “brain fitness.” The technology of polymodal audio‑visual‑tactile entrainment (pAVTE) in the treatment of essential hypertension.
Study of the effects of inhalation of subanesthetic doses of Xe on brain mechanisms of cognitive activity, emotions, and neuronal plasticity in healthy individuals and in patients with depression and panic disorders.
Assessment of the sleep‑wake cycle and quality of nocturnal sleep based on the level of motor activity (actimetry).
Studies on animal‑experimental models
Research is conducted on validated animal models of Parkinson’s disease, Alzheimer’s disease, affective disorders, and schizophrenia, including transgenic mouse lines.
Studies on primary neuronal cultures derived from mouse brain.
Integral approaches to assessing brain functions (mouse behavioral phenotyping): study of motor, social, sexual, depressive‑like behavior, anxiety, and cognitive functions using multimodal software, an automated video recording and behavior analysis system – EthoVision XT (Noldus Information Technology).
Integral approaches to assessing brain functions (mouse behavioral phenotyping): study of conditioned passive avoidance response and startle reflex using automated instruments: the Gemini Avoidance System and the SR-Lab Startle Response System (San Diego Instruments).
Integral approaches to assessing brain functions (mouse behavioral phenotyping): study of behavior and cognitive functions under long‑term observation during group housing of animals using the IntelliCage automated system (TSE Systems).
Integral approaches to assessing brain functions (pharmacological analysis): administration of test substances to mice and rats per os (via gavage), intraperitoneally, subcutaneously, intravenously (including into the retro-orbital sinus), and stereotaxic administration into brain structures using the automated Neurostar Stereo Drive system.
Assistive psychoneurotechnologies
Individual diagnostically guided transcranial magnetic stimulation (rTMS) protocols.
Individual diagnostically guided transcranial electrical stimulation (tES) protocols.
Anti-stress technologies: programs of complex multisensory reintegration using hardware neurotechnologies of entrainment and neurofeedback.
Xenon inhalation therapy for emotional disorders.
Anti-stress technologies: sensory deprivation (clinical floating).
Genetic and molecular biological research
Biobanking of tissue and body fluid samples from laboratory animals and humans.
Identification of molecular correlates of brain processes: assessment of gene transcriptional activity by mRNA levels in brain and blood samples using real‑time RT‑PCR (RT‑qPCR).
Identification of molecular correlates of brain processes: immunohistochemical analysis (IHC) (assessment of protein expression in brain sections and blood cells).
Identification of molecular correlates of brain processes: assessment of protein expression in brain and blood samples using enzyme‑linked immunosorbent assay (ELISA), multiplex assay, and Western blotting.
Identification of neurochemical correlates of brain processes: determination of brain neurotransmitter and their metabolite levels in brain samples using high-performance liquid chromatography (HPLC).